Internal Medicine & Hospital Administration

Biography

Biography: OYEYINKA A. J. (M.Sc.)

Abstract

Sleep deprivation disrupts vital biological processes that are necessary for cognitive ability and physical health, but the effect on haematological indices of anaemic individual are largely unknown. The purpose of this present study is to determine the effect of sleep deprivation on red blood cell morphology in rats induced with iron deficiency anaemia. The haematological parameter of anaemic rats fed with garri was investigated. Garri, popular Nigerian fermented cassava gruel was used to feed rats for twenty-five days and later sleep deprived for 7days. Thirty rats were divided into Groups I, II, III and IV respectively. Group I which was the control had 12 rats and was fed normal rat chow while groups II, III and IV had six rats each and was fed with garri for the period of 25 days. After confirming anaemic status of the rats, they were further grouped into four. The former group I was divided into A and B which are the Normal (A) and Normal sleep deprived (B). The former group II, III and IV were selectively grouped into C (anaemic sleep deprived) for the 7 days sleep deprivation phase. The haematological, serum ferritin level and weights of the animal was analysed. Histological examinations of the bones of the rats were assayed. There was no significant change in the white blood cell count of the rats with iron deficiency anaemia with those of the control which was fed normal rat chow after been sleep deprived. The haemoglobin, platelet count and red blood cell counts of anaemic rats and anaemic sleep deprived rats was decreased when compared with the normal (control) and normal sleep deprived rats. The serum ferritin level of anaemic rats and anaemic sleep deprived was reduced when compared with the control rats. It is suggested that nutrients rich in iron content and most especially fortification of Garri with iron supplements should be adopted in order to prevent iron deficiency anemia in the society.